Biomarker

: Public Class

Created:	9/11/2013 2:21:32 PM
Modified:	3/26/2015 6:04:08 PM

Project:
Author:	BRIDG SCC
Version:	1.0
Phase:	1.0
Status:
Complexity:	Easy
Difficulty:
Priority:
Multiplicity:
Advanced:
UUID:	{86A847B9-2B37-4e1f-8D44-25BB050BCA34}
Appears In:	UML-Based Comprehensive BRIDG Model Diagram, View EX: Experiment, View MB: Molecular Biology

DEFINITION: A measurable and quantifiable biological parameter which serves as index for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc. [Source: adapted from MESH] EXAMPLE(S): Specific enzyme concentration Specific hormone concentration Specific gene phenotype distribution in a population Presence of biological substances OTHER NAME(S): NOTE(S):

Attributes
Associations To
Associations From
Tagged Values
Other Links

Attribute

Public ST
name

Details:

Alias:
Initial:
Stereotype:
Ordered:
Range:	Range:0 to 1
Transient:	False
Derived:	False
IsID:	False

Map:LSDAM=Biomarker.name
Map:LSDAMv2.2.3Plus=Biomarker.name
Map:PGx v1.0=PB.PBMRKR

Notes:

DEFINITION:#lt;br /#gt;#lt;/p#gt;#lt;p#gt;The textual identifier for the biomarker as provided by the assigning source.#lt;br /#gt;#lt;/p#gt;#lt;p#gt;#lt;br /#gt;#lt;/p#gt;#lt;p#gt;EXAMPLE(S):#lt;br /#gt;#lt;/p#gt;#lt;p#gt;G48V#lt;br /#gt;#lt;/p#gt;#lt;p#gt;L10I#lt;br /#gt;#lt;/p#gt;#lt;p#gt;K20R#lt;br /#gt;#lt;/p#gt;#lt;p#gt;M36I#lt;br /#gt;#lt;/p#gt;#lt;p#gt;A71V#lt;br /#gt;#lt;/p#gt;#lt;p#gt;V82T#lt;br /#gt;#lt;/p#gt;#lt;p#gt;#lt;br /#gt;#lt;/p#gt;#lt;p#gt;OTHER NAME(S):#lt;br /#gt;#lt;/p#gt;#lt;p#gt;#lt;br /#gt;#lt;/p#gt;#lt;p#gt;NOTE(S):#lt;br /#gt;#lt;/p#gt;

Public CD
typeCode

Details:

Alias:
Initial:
Stereotype:
Ordered:
Range:	Range:0 to 1
Transient:	False
Derived:	False
IsID:	False

Map:LSDAM=Biomarker.typeCode
Map:LSDAMv2.2.3Plus=Biomarker.typeCode

Notes:

DEFINITION:#lt;br /#gt;#lt;/p#gt;#lt;p#gt;A coded value specifying the basis of the biomarker. #lt;br /#gt;#lt;/p#gt;#lt;p#gt;#lt;br /#gt;#lt;/p#gt;#lt;p#gt;EXAMPLE(S):#lt;br /#gt;#lt;/p#gt;#lt;p#gt;Genetic, Protein, Image-based#lt;br /#gt;#lt;/p#gt;#lt;p#gt;#lt;br /#gt;#lt;/p#gt;#lt;p#gt;OTHER NAME(S):#lt;br /#gt;#lt;/p#gt;#lt;p#gt;#lt;br /#gt;#lt;/p#gt;#lt;p#gt;NOTE(S):#lt;br /#gt;#lt;/p#gt;

Element	Source Role	Target Role
«Comment_Requested» PerformedObservationResult Class	Name: basingBiomarker	Name: basedPerformedObservationResult
Details: DESCRIPTION:<br /></p><p>Each Biomarker might be based on one or more PerformedObservationResult. Each PerformedObservationResult might be the basis of one or more Biomarker.<br /></p><p><br /></p><p>DEFINITION:<br /></p><p><br /></p><p>EXAMPLE(S):<br /></p><p>An image annotation might be the basis for a biomarker.<br /></p><p><br /></p><p>OTHER NAME(S):<br /></p><p><br /></p><p>NOTE(S):<br /></p>
Protein Class	Name: basingBiomarker	Name: basedProtein
Details: DESCRIPTION:<br /></p><p>Each Biomarker might be based on one or more Protein. Each Protein might be the basis of one or more Biomarker.<br /></p><p><br /></p><p>DEFINITION:<br /></p><p><br /></p><p>EXAMPLE(S):<br /></p><p><br /></p><p>OTHER NAME(S):<br /></p><p><br /></p><p>NOTE(S):<br /></p>
NucleicAcidSequenceFeature Class	Name: basingBiomarker	Name: basedNucleicAcidSequenceFeature
Details: DESCRIPTION:<br /></p><p>Each Biomarker might be based on one or more NucleicAcidSequenceFeature. Each NucleicAcidSequenceFeature might be the basis of one or more Biomarker.<br /></p><p><br /></p><p>DEFINITION:<br /></p><p><br /></p><p>EXAMPLE(S):<br /></p><p><br /></p><p>OTHER NAME(S):<br /></p><p><br /></p><p>NOTE(S):<br /></p>

Element	Source Role	Target Role
«Comment_Requested» PerformedObservationResult Class	Name: establishingPerformedObservationResult	Name: establishedBiomarker
Details: DESCRIPTION:<br /></p><p>Each PerformedObservationResult might establish one or more Biomarker. Each Biomarker might be established by one or more PerformedObservationResult.<br /></p><p><br /></p><p>DEFINITION:<br /></p><p>Identifies the finding that results in the identification of a biomarker.<br /></p><p><br /></p><p>EXAMPLE(S):<br /></p><p><br /></p><p>OTHER NAME(S):<br /></p><p><br /></p><p>NOTE(S):<br /></p>

Tag	Value
Map:LSDAM	Biomarker
Details:
Map:LSDAMv2.2.3Plus	Biomarker
Details:

Object	Type	Connection	Direction	Notes
MolecularBiomarker	Class	Generalization	From	DESCRIPTION: Each MolecularBiomarker always specializes one Biomarker. Each Biomarker might be specialized by one MolecularBiomarker. DEFINITION: EXAMPLE(S): OTHER NAME(S): NOTE(S):