: Public Class
Created: 6/6/2006 10:44:46 AM
Modified: 8/26/2017 2:24:23 AM
Project:
Advanced:
DEFINITION: <br/>A functional unit of heredity that occupies a specific position (locus) on a particular chromosome, is capable of reproducing itself exactly at each cell division, and directs the formation of a protein or other product.<br/><br/>Comment Requested:  In interest of re-using existing standards, should the above definition of Gene be replaced by the following from the NLM - <font color="#ff0000"> The basic physical and functional unit of heredity. It is made up of DNA and act as instructions to make molecules called proteins.  [Source: http://ghr.nlm.nih.gov/handbook/basics/gene]</font><br/><br/><br/>EXAMPLE(S):<br/>BRCA1 gene<br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
Attribute
Public ID
  identifier
Details:
Map:LSDAMv2.2.3Plus=GeneIdentifier.identifier
Notes: DEFINITION:<br/>A unique symbol that establishes the identity of the gene.  <br/><br/>EXAMPLE(S):<br/>For the 14-3-3 eta gene (a protein), here are some identifiers from various organizations: <br/><ul>
<li>ENSG00000128245 from Ensembl  </li><li>12853 from HGNC  </li><li>00215 from HPRD  </li><li>7533 from NCBI</li></ul>
<br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
Public DSET<SC>
  name
Details:
Map:LSDAMv2.2.3Plus=Gene.name
Map:PGx v1.0=PB.PBGENRI
Notes: DEFINITION:<br/>The English language identifier of a gene as defined by the specified source.<br/><br/>EXAMPLE(S): <br/>Breast cancer type 1 susceptibility gene<br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
Public DSET<SC>
  symbol
Details:
Map:LSDAMv2.2.3Plus=Gene.symbol
Notes: DEFINITION:<br/>A conventional sign used for representing the gene, based on the identified source.<br/><br/>EXAMPLE(S): <br/><font color="#0f0f0f">As a string with an optional code, an example of Gene.symbol is as follows:  the value "BRCA1" is both the string and the code and the code system name is "HGNC".</font><br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
Element Source Role Target Role
Protein
Class  
Name: encodingGene
 
Name: encodedProtein
 
Details:
DESCRIPTION:<br/>Each Gene might encode one or more Protein.  Each Protein might be encoded by one or more Gene.<br/><br/>DEFINITION:<br/><br/>EXAMPLE(S):<br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
MessengerRNA
Class  
Name: transcribedFromGene
 
Name: transcribedToMessengerRNA
 
Details:
DESCRIPTION:<br/>Each Gene might be transcribed to one or more MessengerRNA.  Each MessengerRNA might be transcribed from one or more Gene.<br/><br/>DEFINITION:<br/><br/>EXAMPLE(S):<br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
Element Source Role Target Role
Pathway
Class  
Name: involvingPathway
 
Name: involvedGene
 
Details:
DESCRIPTION:<br/>Each Pathway might involve one or more Gene. Each Gene might be involved in one or more Pathway.<br/><br/>DEFINITION:<br/><br/>EXAMPLE(S):<br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
Exon
Class  
Name: locatedExon
 
Name: locatingGene
 
Details:
DESCRIPTION:<br/>Each Exon might be located in one or more Gene.  Each Gene might have one or more Exon.<br/><br/>DEFINITION:<br/><br/>EXAMPLE(S):<br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
Intron
Class  
Name: locatedIntron
 
Name: locatingGene
 
Details:
DESCRIPTION:<br/>Each Intron might be located in one or more Gene.  Each Gene might have one or more Intron.<br/><br/>DEFINITION:<br/><br/>EXAMPLE(S):<br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
MolecularBiomarkerGroup
Class  
Name: basingMolecularBiomarkerGroup
 
Name: basedGene
 
Details:
DESCRIPTION:<br/>Each MolecularBiomarkerGroup might be based on one or more Gene. Each Gene might be the basis of one or more MolecularBiomarkerGroup.<br/><br/>DEFINITION:<br/><br/>EXAMPLE(S):<br/><br/>OTHER NAME(S):<br/><br/>NOTE(S):<br/>
Tag Value
Map:LSDAMv2.2.3Plus Gene
Details:
 
Map:PGx v1.0 PB.PBGENTYP
Details:
 
Object Type Connection Direction Notes
NucleicAcidSequenceFeature Class Generalization To DESCRIPTION: Each Gene always specializes one NucleicAcidSequenceFeature. Each NucleicAcidSequenceFeature might be specialized by one Gene. DEFINITION: EXAMPLE(S): OTHER NAME(S): NOTE(S):